Case Report
Quadrantic Partial Thickness
Sclerectomy for Treatment of Uveal Effusion Syndrome
Muhammad
Tariq Khan, Sidrah Riaz, Zaheer ud Din Aqil Qazi
Pak J Ophthalmol 2017, Vol. 33, No. 2
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See
end of article for authors
affiliations …..……………………….. Correspondence
to: Dr.
Muhammad Tariq Khan Associate
Professor (Ophthalmology) Head
of Vitreoretinal Department Akhtar
Saeed Trust Hospital, Lahore Email: stariq69@hotmail.com |
Purpose: To report our experience with
partial thickness sclerectomy in patients diagnosed as idiopathic uveal
effusion syndrome. Study design: Prospective case series Place and Duration of Study: Layton
Rehmatullah Benevolent Trust (LRBT) eye hospital, Lahore January 2010 to August
2013. Material and Methods: Four
eyes of two patients (one male and one female) with bilateral idiopathic
uveal syndrome were included in study. The diagnosis was clinical. Results: Both patients showed
improvement clinically in visual acuity and in fundoscopy in term of retinal
reattachment. Conclusion: Patient with uveal effusion
syndrome responded better to surgical procedures like sclerectomy and didn’t
respond to medical treatment. Key words: Uveal effusion syndrome,
quadrantic sclerectomy, exudative retinal detachment, intraocular pressure
(IOP). |
It was 19631 when Schepens and
Brockhurst coined the term “uveal effusion”. They reported choroidal and
ciliary body detachment with exudation. In 1982, Gass and Jallow introduced term
“idiopathic uveal effusion syndrome” to describe serous detachment of choroid,
ciliary body and retina of unknown origin2. It is a rare ocular
disorder affecting predominantly healthy young males and involvement is
commonly bilateral. It is a diagnosis of exclusion. The exudative retinal
detachment follows a typical pattern which begins inferiorly. The anterior fibers
of sclera attaching the choroid are long and tangentially oriented than
posterior fibers so more fluid accumulation is seen anteriorly3. Other
features are dilated episcleral vessels, blood in canal of schlemm, normal
intraocular pressure (IOP), elevation of sub retinal and cerebrospinal fluid
(CCF) proteins4,5. Marked anatomical alterations may be evident at
the level of retinal pigment epithelium with so called “leopard spot” hyper
pigmentation1. There is no evident intraocular inflammation1.
The natural history of disease shows activation and remission pattern and if
patient is not treated timely, there may be permanent visual loss due to
structural damage to photoreceptors and intra-retinal fibrosis. The milder
forms usually resolve but visual prognosis for eyes presenting with bullous
retinal detachment is poor6.
It responds poorly to
medical treatment like corticosteroids and anti metabolites6 and non-surgical
treatment. Response to surgical options like scleral buckling and pars plana
vitrectomy (PPV) is also not convincing. The successful retinal re attachment can
be obtained by scleral thinning procedures like quadrantic partial thickness sclerectomy.
MATERIALS AND METHODS
Four eyes of two patients (one
male and one female) with bilateral idiopathic uveal syndrome were included in
study. The diagnosis was clinical. The patients with posterior scleritis, inflammatory
orbital disease, arteriovenous fistula, pan retinal laser, recent retinal
surgery, ocular trauma and ocular neoplasm were excluded. There was no history
of taking drugs like sulfonamide and acetazolamide. The technique of
sclerectomy involved the following steps. 360 degree peritomy around limbus is
done. Four recti muscles are secured
with bridle sutures as for retinal buckling procedure. One quadrant is exposed at a time. After
securing homeostasis a rectangular area is marked with scleral marker 7 mm from
the limbus measuring 10mm horizontally and 8 mm vertically. With 15 no blade a
partial thickness scleral flap, almost 80% in thickness is raised and removed.
The scleral thickness at this place is now 20%. The procedure is repeated in
all four quadrants. Subretinal fluid may or may not be drained. The author
recommends the drainage for early rehabilitation Fig 1.
Fig. 1: Diagramtic
representation of the procedure.
Case 1
A young male presented
with gradual decrease in vision in both eyes for the last six months. His
vision was perception of light (PL) in both eyes with exudative retinal
detachment seen on fundus examination, fig. 2. His intraocular pressure (IOP)
was 10 mm Hg both eyes. Quadrantic sclerectomy was done in both eyes with 1
week interval, fig. 3. Subretinal fluid (SRF) was drained in left eye but not
in right eye. Hypotony was managed in left eye with intravitreal C3F8
injection after SRF drainage.
Fig. 2: Preoperative
fundus picture.
Case 2
A young female presented
with gradual decrease in vision for the last 9 months. The vision was light
perception (PL) in both eyes with normal IOP (8 mm Hg in right 6 mm Hg in
left). She was hypermetropic of +7 diopter sphere in both eyes. Her axial
length was 19 mm in both eyes. Her right eye was operated and quadrantic
sclerectomy but she didn’t report back for left eye surgery after 2 follow up
visits.
Table 1: Patient data showing pre and post-operative vision and IOP.
Serial No. |
Eye |
Pre-Operative |
Post-Operative |
||||||
Visual Acuity |
IOP (mm Hg) |
Visual Acuity |
IOP (mm Hg) |
||||||
1 wk |
3 wks |
12 wks |
1 wk |
3 wks |
12 wks |
||||
Case 01 Male |
Rt |
PL+ |
10 |
6/36 |
6/24 |
6/24 |
10 |
10 |
10 |
Lt |
PL+ |
10 |
6/36 |
6/24 |
6/24 |
12 |
10 |
10 |
|
Case 02 Female |
Rt |
PL+ |
8 |
6/36 |
6/36 |
6/36 |
10 |
12 |
10 |
Lt |
PL+ |
10 |
-surgery not done |
- |
- |
- |
- |
- |
RESULTS
Three eyes were operated and quadrantic
sclerectomy was performed in these. Male patient showed improvement in vision
which was faster in left eye than right eye, in which sclerectomy was
accompanied by SRF drainage and intravitreal C3F8gas
injection. Patient’s vision improved from PL to 6/24 in four weeks
postoperatively in left eye. In the right eye it improved to 6/24 in six weeks.
This was the eye in which SRF was not drained. His retina was attached in both
eyes, fig. 4. He was examined at his last follow up visit on September 2014 and
he had bilateral best corrected vision of 6/18 with normal IOP.
Female was examined one and three weeks
postoperatively. Her vision improved from PL to 6/36 with glasses in her right
eye. Her retina was attached. She was lost in follow-up.
Both patients were
followed one week, three weeks and twelve weeks postoperatively.
Fig. 3: Quadrantic Sclerectomy.
Fig. 4: Fundus Picture -
1 month postoperatively.
DISCUSSION
Two patients with idiopathic uveal effusion
syndrome were operated. It is a type of scleropathy affecting choroidal fluid
dynamics. Abnormally thick sclera and short axial length were common in both
eyes. Quadrantic sclerectomy in 3 eyes was successful in attaining retinal re attachment.
Following scleral resection all 3 eyes showed retinal re attachment and
improvement in visual acuity.
Theories regarding pathogenesis of uveal
effusion syndrome suggest that it is more common in nanophthalmic eyes7
where scleropathy is congenital and abnormally thick sclera8 compresses
vortex veins leading to impeded drainage. Similarly thick sclera is also seen
in patients suffering from glycogen storage disease, mucopolysaccharidosis
(Hunter syndrome)9 where sclera is thick due to increased deposition
of mucopolysaccharides. Decompression of vortex veins was attempted by Gass and
he found that full thickness sclera incisions were effective in obtaining
reattachment of retina, supporting the hypothesis that it was primarily scleral
thickening causing uveal effusion by obstructing protein diffusion (mainly
albumin) out of sclera and obstruction of vortex veins. The thick sclera
hinders trans-scleral protein diffusion which results in protein accumulation
in choroidal extra vascular space. In the absence of any known systemic
disorder, abnormal deposition of different materials is the cause of scleral
thickening10,11,12. The intraocular pressure is one of the factors
which determines trans-scleral flow of proteins in the eye13,14,15. Quadrantic
sclerotomy was successful in treating uveal effusion syndrome by relieving choroidal
effusion and non rhegmatogenous retinal detachment16,17. It supports
the hypothesis that thick sclera prevents protein diffusion and decreasing
scleral thickness can improve fluid outflow18.
Vortex vein
decompression was first suggested by Schaffer in 19756. Success of
scleral thinning procedure was also reported by Brockhurst in 198019,20.
CONCLUSION
Patient with uveal
effusion syndrome responded better to surgical procedures like sclerectomy and
didn’t respond to medical treatment.
Author’s Affiliation
Dr.
Muhammad Tariq Khan
Associate
Professor (Ophthalmology)
Head of
Vitreoretinal Department
Akhtar
Saeed Trust Hospital, Lahore
Dr.
Sidrah Riaz
Assistant
Professor (Ophthalmology)
Akhtar
Saeed Trust Hospital, Lahore
Dr.
Zaheer ud Din Aqil Qazi,
Consultant
Ophthalmologist,
LRBT
eye hospital, Lahore
Role of Authors
Dr.
Muhammad Tariq Khan
Study
design, Manuscript drafting, surgery performed
Dr.
Sidrah Riaz
Data
collection, Data analysis, article writing, Composition
Dr. Zaheer
ud Din Aqil Qazi
Manuscript
review
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